Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

Background: Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD. Aims: Ten hydroxylated monocarbonyl curcumin derivatives were desig...

Full description

Bibliographic Details
Main Authors: Dimitris Matiadis, See-Ting Ng, Eric H.-L. Chen, Georgia Nigianni, Veroniki P. Vidali, Aleksander Canko, Rita P.-Y. Chen, Marina Sagnou
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
monocarbonyl curcumin derivatives
neprilysin
amyloid cleavage
Aβ amyloid peptide
Alzheimer’s disease
Online Access:https://www.mdpi.com/2227-9059/9/8/955

Internet

https://www.mdpi.com/2227-9059/9/8/955

Similar Items