CD73-Adenosine A1R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP3-Ca2+/DAG-PKC Signaling Pathway

CD73-Adenosine A1R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP3-Ca2+/DAG-PKC Signaling Pathway

Alcohol-related liver fibrosis (ALF) is a form of alcohol-related liver disease (ALD) that generally occurs in response to heavy long-term drinking. Ecto-5′-nucleotidase (NT5E), also known as CD73, is a cytomembrane protein linked to the cell membrane via a GPI anchor that regulates the conversion o...

Full description

Bibliographic Details
Main Authors: Zhenni Liu, Xue Wu, Qi Wang, Zixuan Li, Xueqi Liu, Xiaodong Sheng, Hong Zhu, Mengda Zhang, Junrui Xu, Xiaowen Feng, Baoming Wu, Xiongwen Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
CD73
adenosine A1 receptor
alcohol-related liver fibrosis
apoptosis
PLC-IP3-Ca2+/DAG-PKC signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.922885/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.922885/full

Similar Items