Germ Cell Maintenance and Sustained Testosterone and Precursor Hormone Production in Human Prepubertal Testis Organ Culture with Tissues from Boys 7 Years+ under Conditions from Adult Testicular Tissue

Germ Cell Maintenance and Sustained Testosterone and Precursor Hormone Production in Human Prepubertal Testis Organ Culture with Tissues from Boys 7 Years+ under Conditions from Adult Testicular Tissue

Human prepubertal testicular tissues are rare, but organ culture conditions to develop a system for human in vitro-spermatogenesis are an essential option for fertility preservation in prepubertal boys subjected to gonadotoxic therapy. To avoid animal testing in line with the 3Rs principle, organ cu...

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Bibliographic Details
Main Authors: Neels Lennart Aden, Matthias Bleeke, Uwe R. Kordes, Bianka Brunne, Barbara Holstermann, Ronald Biemann, Uta Ceglarek, Armin Soave, Andrea Salzbrunn, Stefan W. Schneider, Kathrein von Kopylow
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
prepubertal boys
fertility preservation
testis organ culture
in vitro culture
spermatogonia
spermatogonial stem cells
Online Access:https://www.mdpi.com/2073-4409/12/3/415

Internet

https://www.mdpi.com/2073-4409/12/3/415

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