Chemically augmented malaria sporozoites display an altered immunogenic profile

Chemically augmented malaria sporozoites display an altered immunogenic profile

Despite promising results in malaria-naïve individuals, whole sporozoite (SPZ) vaccine efficacy in malaria-endemic settings has been suboptimal. Vaccine hypo-responsiveness due to previous malaria exposure has been posited as responsible, indicating the need for SPZ vaccines of increased immunogenic...

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Bibliographic Details
Main Authors: Nikolas Duszenko, Roos van Schuijlenburg, Severine Chevalley-Maurel, Danny M. van Willigen, Laura de Bes-Roeleveld, Stefanie van der Wees, Chanel Naar, Els Baalbergen, Graham Heieis, Anton Bunschoten, Aldrik H. Velders, Blandine Franke-Fayard, Fijs W. B. van Leeuwen, Meta Roestenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
malaria
vaccine
adjuvant
immunogenicity
supramolecular chemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1204606/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1204606/full

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