Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications
Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bi...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/5/965 |
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| author | Ibrahim E. Sallam Amr Abdelwareth Heba Attia Ramy K. Aziz Masun Nabhan Homsi Martin von Bergen Mohamed A. Farag |
| author_facet | Ibrahim E. Sallam Amr Abdelwareth Heba Attia Ramy K. Aziz Masun Nabhan Homsi Martin von Bergen Mohamed A. Farag |
| author_sort | Ibrahim E. Sallam |
| collection | DOAJ |
| description | Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota–tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits. |
| first_indexed | 2024-03-10T11:49:39Z |
| format | Article |
| id | doaj.art-e890381773a049e3a01abf07d454c4a9 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T11:49:39Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-e890381773a049e3a01abf07d454c4a92023-11-21T17:50:29ZengMDPI AGMicroorganisms2076-26072021-04-019596510.3390/microorganisms9050965Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health ImplicationsIbrahim E. Sallam0Amr Abdelwareth1Heba Attia2Ramy K. Aziz3Masun Nabhan Homsi4Martin von Bergen5Mohamed A. Farag6Pharmacognosy Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October City 12566, EgyptChemistry Department, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, EgyptDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo 11562, EgyptDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo 11562, EgyptHelmholtz-Centre for Environmental Research-UFZ GmbH, Department of Molecular Systems Biology, 04318 Leipzig, GermanyHelmholtz-Centre for Environmental Research-UFZ GmbH, Department of Molecular Systems Biology, 04318 Leipzig, GermanyPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, EgyptTannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota–tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits.https://www.mdpi.com/2076-2607/9/5/965tanninsgut microbiotamutual interactionpolyphenolsbiotransformationmolecular motifs |
| spellingShingle | Ibrahim E. Sallam Amr Abdelwareth Heba Attia Ramy K. Aziz Masun Nabhan Homsi Martin von Bergen Mohamed A. Farag Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications Microorganisms tannins gut microbiota mutual interaction polyphenols biotransformation molecular motifs |
| title | Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications |
| title_full | Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications |
| title_fullStr | Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications |
| title_full_unstemmed | Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications |
| title_short | Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications |
| title_sort | effect of gut microbiota biotransformation on dietary tannins and human health implications |
| topic | tannins gut microbiota mutual interaction polyphenols biotransformation molecular motifs |
| url | https://www.mdpi.com/2076-2607/9/5/965 |
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