miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a

miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a

Compromised cardiac function is a hallmark for heart failure, mostly appearing as decreased contractile capacity due to dysregulated calcium handling. Unfortunately, the underlying mechanism causing impaired calcium handling is still not fully understood. Previously the miR-132/212 family was identi...

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Bibliographic Details
Main Authors: Zhiyong Lei, Christine Wahlquist, Hamid el Azzouzi, Janine C. Deddens, Diederik Kuster, Alain van Mil, Agustin Rojas-Munoz, Manon M. Huibers, Mark Mercola, Roel de Weger, Jolanda Van der Velden, Junjie Xiao, Pieter A. Doevendans, Joost P. G. Sluijter
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
miR-132/212 family
cardiac contractility
heart failure
myocardial infarction
knockout mice
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.592362/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.592362/full

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