Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV

Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV

Abstract Microglia are implicated in Alzheimer’s Disease (AD) pathogenesis. In a middle-aged cohort enriched for neuroinflammation, we asked whether microgliosis was related to neocortical amyloid beta (A $$\upbeta$$ β ) deposition and neuronal phosphorylated tau (p-tau), and whether microgliosis pr...

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Bibliographic Details
Main Authors: Jacinta Murray, Gregory Meloni, Etty P. Cortes, Ariadna KimSilva, Michelle Jacobs, Alyssa Ramkissoon, John F. Crary, Susan Morgello
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Acta Neuropathologica Communications
Subjects:
Microglia
HIV
Amyloid beta
Tau
Online Access:https://doi.org/10.1186/s40478-022-01375-y

Internet

https://doi.org/10.1186/s40478-022-01375-y

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