Enterohepatic Takeda G-Protein Coupled Receptor 5 Agonism in Metabolic Dysfunction-Associated Fatty Liver Disease and Related Glucose Dysmetabolism

Enterohepatic Takeda G-Protein Coupled Receptor 5 Agonism in Metabolic Dysfunction-Associated Fatty Liver Disease and Related Glucose Dysmetabolism

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major health concern with no approved pharmacological therapies. Molecules developed to activate the bile acid-receptor TGR5 regulate pathways involved in MALFD pathogenesis, but the therapeutic value of TGR5 activation on the active...

Full description

Bibliographic Details
Main Authors: Justine Gillard, Corinne Picalausa, Christoph Ullmer, Luciano Adorini, Bart Staels, Anne Tailleux, Isabelle A. Leclercq
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Nutrients
Subjects:
MAFLD
NASH
metabolic syndrome
TGR5
INT-777
RO5527239
Online Access:https://www.mdpi.com/2072-6643/14/13/2707

Internet

https://www.mdpi.com/2072-6643/14/13/2707

Similar Items