Development of a Patient-Derived 3D Immuno-Oncology Platform to Potentiate Immunotherapy Responses in Ascites-Derived Circulating Tumor Cells

Development of a Patient-Derived 3D Immuno-Oncology Platform to Potentiate Immunotherapy Responses in Ascites-Derived Circulating Tumor Cells

High-grade serous ovarian cancer (HGSOC) is responsible for the majority of gynecology cancer-related deaths. Patients in remission often relapse with more aggressive forms of disease within 2 years post-treatment. Alternative immuno-oncology (IO) strategies, such as immune checkpoint blockade (ICB)...

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Bibliographic Details
Main Authors: Thomas J. Gerton, Allen Green, Marco Campisi, Minyue Chen, Iliana Gjeci, Navin Mahadevan, Catherine A. A. Lee, Ranjan Mishra, Ha V. Vo, Koji Haratani, Ze-Hua Li, Kathleen T. Hasselblatt, Bryanna Testino, Trevor Connor, Christine G. Lian, Kevin M. Elias, Patrick Lizotte, Elena V. Ivanova, David A. Barbie, Daniela M. Dinulescu
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
PDOTS
ovarian cancer
ascites
epigenetic
methylation
ICB
Online Access:https://www.mdpi.com/2072-6694/15/16/4128

Internet

https://www.mdpi.com/2072-6694/15/16/4128

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