Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

Summary: The development of hybrid compounds has been widely considered as a promising strategy to circumvent the difficulties that emerge in cancer treatment. The well-established strategy of adding acetyl groups to certain drugs has been demonstrated to enhance their therapeutic efficacy. Based on...

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Bibliographic Details
Main Authors: Wafaa S. Ramadan, Maha M. Saber-Ayad, Ekram Saleh, Hajjaj H.M. Abdu-Allah, Abdel-nasser A. El-Shorbagi, Varsha Menon, Hamadeh Tarazi, Mohammad H. Semreen, Nelson C. Soares, Shirin Hafezi, Thenmozhi Venkatakhalam, Samrein Ahmed, Osamu Kanie, Rifat Hamoudi, Raafat El-Awady
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Pharmaceutical science
Computational chemistry
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223027360

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http://www.sciencedirect.com/science/article/pii/S2589004223027360

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