BRD4-targeting PROTAC as a unique tool to study biomolecular condensates

Abstract Biomolecular condensates play key roles in various biological processes. However, specific condensation modulators are currently lacking. PROTAC is a new technology that can use small molecules to degrade target proteins specifically. PROTAC molecules are expected to regulate biomolecular c...

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Bibliographic Details
Main Authors: Yi Shi, Yuan Liao, Qianlong Liu, Zhihao Ni, Zhenzhen Zhang, Minglei Shi, Pilong Li, Haitao Li, Yu Rao
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00544-0