High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer

High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer

Summary: Immunotherapy targeting glucocorticoid-induced TNFR-related protein (GITR) exhibited strong anti-tumor capacity in mouse model but poor efficacy in clinical trials. This may be attributed to the different GITR expression mode between human and mouse. In this study, we analyzed single-cell R...

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Bibliographic Details
Main Authors: Shouyu Ke, Feng Xie, Yixian Guo, Jieqiong Chen, Zeyu Wang, Yimeng Yu, Haigang Geng, Danhua Xu, Xu Liu, Xiang Xia, Fengrong Yu, Chunchao Zhu, Zizhen Zhang, Gang Zhao, Bin Li, Wenyi Zhao
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Immunology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222018016

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222018016

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