Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells

Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells

Abstract Background One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal carcinogenesis remain elusive. Here, we provide evidence for CD80 overexp...

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Bibliographic Details
Main Authors: Chiara Marchiori, Melania Scarpa, Andromachi Kotsafti, Susan Morgan, Matteo Fassan, Vincenza Guzzardo, Andrea Porzionato, Imerio Angriman, Cesare Ruffolo, Stefania Sut, Stefano Dall’Acqua, Romeo Bardini, Raffaele De Caro, Carlo Castoro, Marco Scarpa, Ignazio Castagliuolo
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Immune surveillance
Colorectal cancer
Dysplasia
CD80
Online Access:http://link.springer.com/article/10.1186/s13046-019-1205-0

Internet

http://link.springer.com/article/10.1186/s13046-019-1205-0

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