Screening assay for inhibitors of a recombinant Streptococcus pneumoniae UDP-glucose pyrophosphorylase

Screening assay for inhibitors of a recombinant Streptococcus pneumoniae UDP-glucose pyrophosphorylase

The UDP-glucose pyrophosphorylase of Streptococcus pneumoniae (GalUSpn) is absolutely required for the biosynthesis of capsular polysaccharide, the sine qua non virulence factor of pneumococcus. Since the eukaryotic enzymes are completely unrelated to their prokaryotic counterparts, we propose that...

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Bibliographic Details
Main Authors: Agustín Zavala, Verónica Kovacec, Gustavo Levín, Albertina Moglioni, María Victoria Miranda, Ernesto García, Laura Bonofiglio, Marta Mollerach
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Antibacterial target
pneumococcus
UTP:glucose 1-phosphate uridylyltransferase
virulence inhibitors
Online Access:http://dx.doi.org/10.1080/14756366.2016.1247055

Internet

http://dx.doi.org/10.1080/14756366.2016.1247055

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