C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Abstract Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear. Furthermore, its potential as a therapeutic target t...

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Bibliographic Details
Main Authors: Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Acta Neuropathologica Communications
Subjects:
C5aR1
Alzheimer’s disease
Microglia
Complement
Neuroinflammation
DAM
Online Access:https://doi.org/10.1186/s40478-022-01416-6

Internet

https://doi.org/10.1186/s40478-022-01416-6

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