Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas

Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas

Fibroblast growth factor receptor 4 (FGFR4) aberrant expression and activity have been linked to the pathogenesis of a variety of cancers including rhabdomyosarcomas (RMS). We found that treatment of alveolar rhabdomyosarcoma (aRMS) cells with Guadecitabine (SGI-110), a next-generation DNA methyltra...

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Bibliographic Details
Main Authors: Emad Darvishi, Katherine Slemmons, Zesheng Wan, Sheetal Mitra, Xiaogang Hou, Jean Hugues Parmentier, Yong-Hwee Eddie Loh, Lee J. Helman
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Fibroblast growth factor receptor 4 (FGFR4)
Alveolar rhabdomyosarcoma (aRMS)
Guadecitabine (SGI-110)
Epigenetic marks
Histone lysine demethylase 5B (KDM5B)
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301184

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http://www.sciencedirect.com/science/article/pii/S1476558620301184

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