The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus.

The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus.

Tacrolimus (FK506) is an immunosuppressive drug that binds to the immunophilin FKBPB12. The FK506-FKBP12 complex associates with calcineurin and inhibits its phosphatase activity, resulting in inhibition of nuclear translocation of nuclear factor of activated T-cells (NFAT). There is increasing data...

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Bibliographic Details
Main Authors: Sharareh Siamakpour-Reihani, Joseph Caster, Desh Bandhu Nepal, Andrew Courtwright, Eleanor Hilliard, Jerry Usary, David Ketelsen, David Darr, Xiang Jun Shen, Cam Patterson, Nancy Klauber-Demore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3108822?pdf=render

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http://europepmc.org/articles/PMC3108822?pdf=render

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