Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques.

Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques.

Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central nervous system (CNS) infection is confounded by poor penetration of the blood brain barrier (BBB). Typically, antibody concentrations in the...

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Bibliographic Details
Main Authors: Jing Wen, Tracy Cheever, Lan Wang, Di Wu, Jason Reed, John Mascola, Xuejun Chen, Cuiping Liu, Amarendra Pegu, Jonah B Sacha, Yunfeng Lu, Nancy L Haigwood, Irvin S Y Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009738

Internet

https://doi.org/10.1371/journal.ppat.1009738

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