The Possible Contribution of P-Glycoprotein in the Protective Effect of Paeonol against Methotrexate-Induced Testicular Injury in Rats

The Possible Contribution of P-Glycoprotein in the Protective Effect of Paeonol against Methotrexate-Induced Testicular Injury in Rats

Paeonol, a phenolic ingredient in the genus <i>Paeonia</i>, possesses antioxidant and anti-inflammatory effects. Methotrexate (MTX) is a commonly used chemotherapeutic agent; however, its germ cell damage is a critical problem. P-glycoprotein (P-gp), an efflux transporter, is a member of...

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Bibliographic Details
Main Authors: Mohamed A. Morsy, Asmaa M. Abdel-Aziz, Sara M. N. Abdel-Hafez, Katharigatta N. Venugopala, Anroop B. Nair, Seham A. Abdel-Gaber
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceuticals
Subjects:
paeonol
methotrexate
P-glycoprotein
testicular injury
oxidative stress
tumor necrosis factor-α
Online Access:https://www.mdpi.com/1424-8247/13/9/223

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https://www.mdpi.com/1424-8247/13/9/223

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