Multifunctional Derivatives of Spiropyrrolidine Tethered Indeno-Quinoxaline Heterocyclic Hybrids as Potent Antimicrobial, Antioxidant and Antidiabetic Agents: Design, Synthesis, In Vitro and In Silico Approaches

Multifunctional Derivatives of Spiropyrrolidine Tethered Indeno-Quinoxaline Heterocyclic Hybrids as Potent Antimicrobial, Antioxidant and Antidiabetic Agents: Design, Synthesis, In Vitro and In Silico Approaches

To combat emerging antimicrobial-resistant microbes, there is an urgent need to develop new antimicrobials with better therapeutic profiles. For this, a series of 13 new spiropyrrolidine derivatives were designed, synthesized, characterized and evaluated for their in vitro antimicrobial, antioxidant...

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Bibliographic Details
Main Authors: Nouha Bouali, Manel Ben Hammouda, Iqrar Ahmad, Siwar Ghannay, Amira Thouri, Amal Dbeibia, Harun Patel, Walid Sabri Hamadou, Karim Hosni, Mejdi Snoussi, Mohd Adnan, Md Imtaiyaz Hassan, Emira Noumi, Kaïss Aouadi, Adel Kadri
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
spiropyrrolidine derivatives
antimicrobial
antioxidant
antidiabetic
ADME
molecular docking and dynamic simulation
Online Access:https://www.mdpi.com/1420-3049/27/21/7248

Internet

https://www.mdpi.com/1420-3049/27/21/7248

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