Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel Grade 10 to Establish a Correlation between In Vitro and In Vivo Results

Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel Grade 10 to Establish a Correlation between In Vitro and In Vivo Results

In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer <i>w</i>/<i>w</i> ratios (10:3, 10:4, and 10:5). The matrices were...

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Bibliographic Details
Main Authors: Kamran Ahmad Khan, Ashfaq Ahmad, Carlotta Marini, Mario Nicotra, Alessandro Di Cerbo, Fazal-Ur-Rehman, Naveed Ullah, Gul Majid Khan
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
controlled release
losartan potassium
Ethocel grade 10
in vitro-in vivo correlation
Online Access:https://www.mdpi.com/1999-4923/16/2/186

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https://www.mdpi.com/1999-4923/16/2/186

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