Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters

The potassium channel selectivity filter is responsible for conduction and selectivity of K + over other cations. Here, the authors use a combination of single molecule FRET, non-canonical fluorescent amino acid incorporation, and single channel patch-clamp electrophysiology, to establish the genera...

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Bibliographic Details
Main Authors: Marcos Matamoros, Xue Wen Ng, Joshua B. Brettmann, David W. Piston, Colin G. Nichols
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35756-7