Effect of oligonucleotide MT01 delivered by N-isopropylacrylamide modified polyethyleneimine for bone regeneration

Effect of oligonucleotide MT01 delivered by N-isopropylacrylamide modified polyethyleneimine for bone regeneration

Objective: This study aimed to investigate the regulatory effect of N-isopropylacrylamide-modified polyethyleneimine (PEN)-delivered oligodeoxynucleotide (ODN) MT01 on bone regeneration in vitro and in vivo.Methods: A polyethylenimine (PEI) derivative, PEN, was constructed through Michael addition a...

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Bibliographic Details
Main Authors: Qian Zhang, Xingyuan Qu, Chen Liang, Hongyan Li, Siyu Du, Chang Wang, Yuandong Xie, Yi Zheng, Lei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
PEN
MT01
bone regeneration
gene therapy
oligodeoxynucleotide
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1204571/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1204571/full

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