Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential

Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential

Vascular homeostasis and regeneration in ischemic tissue relies on intrinsic competence of the tissue to rapidly recruit endothelial cells for vascularization. The mononuclear cell (MNC) fraction of blood contains circulating progenitors committed to endothelial lineage. These progenitors give rise...

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Bibliographic Details
Main Authors: Dimitar Tasev, Laura Dekker-Vroling, Michiel van Wijhe, Henk J. Broxterman, Pieter Koolwijk, Victor W. M. van Hinsbergh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Medicine
Subjects:
ECFCs
hypoxia
colony growth
angiogenesis
tissue repair
proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2018.00356/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2018.00356/full

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