hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins

hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins

Botulinum neurotoxins (BoNTs) are zinc metalloproteases that block neurotransmitter release at the neuromuscular junction (NMJ). Their high affinity for motor neurons combined with a high potency have made them extremely effective drugs for the treatment of a variety of neurological diseases as well...

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Bibliographic Details
Main Authors: Juliette Duchesne De Lamotte, Sylvain Roqueviere, Hélène Gautier, Elsa Raban, Céline Bouré, Elena Fonfria, Johannes Krupp, Camille Nicoleau
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
botulinum neurotoxins
in vitro translational models
human induced pluripotent stem cells
motor neurons
neuromuscular junction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.617867/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.617867/full

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