Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration

Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a leading cause of blindness, and elucidating its underlying disease mechanisms is vital to the development of appropriate therapeutics. We identified differentially expressed genes (DEGs) and differentially spliced genes (DSGs) across the clinical stages of...

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Bibliographic Details
Main Authors: Treefa Shwani, Charles Zhang, Leah A. Owen, Akbar Shakoor, Albert T. Vitale, John H. Lillvis, Julie L. Barr, Parker Cromwell, Robert Finley, Nadine Husami, Elizabeth Au, Rylee A. Zavala, Elijah C. Graves, Sarah X. Zhang, Michael H. Farkas, David A. Ammar, Karen M. Allison, Amany Tawfik, Richard M. Sherva, Mingyao Li, Dwight Stambolian, Ivana K. Kim, Lindsay A. Farrer, Margaret M. DeAngelis
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
age-related macular degeneration (AMD)
intermediate AMD (iAMD)
neovascular AMD (NEO)
macular retinal pigment epithelium (RPE)/choroid
macular retina
tissue-specific gene expression
Online Access:https://www.mdpi.com/2073-4409/12/23/2668

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https://www.mdpi.com/2073-4409/12/23/2668

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