Efficient rejoining of DNA double-strand breaks despite increased cell-killing effectiveness following spread-out Bragg peak carbon-ion irradiation

Efficient rejoining of DNA double-strand breaks despite increased cell-killing effectiveness following spread-out Bragg peak carbon-ion irradiation

Radiotherapy of solid tumors with charged particles holds several advantages in comparison to photon therapy; among them conformal dose distribution in the tumor, improved sparing of tumor-surrounding healthy tissue, and an increased relative biological effectiveness (RBE) in the tumor target-volume...

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Bibliographic Details
Main Authors: Nicole Bernadette Averbeck, Jana eTopsch, Michael eScholz, Wilma eKraft-Weyrather, Marco eDurante, Gisela eTaucher-Scholz
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Oncology
Subjects:
Heavy Ions
DSB repair
RBE
error-prone DNA repair
carbon-ion radiotherpy
DSB complexity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00028/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00028/full

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