Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal

Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal

The hepatic enzyme bile acid CoA:amino acid N-acyltransferase (BAT) catalyzes the formation of amino acid-conjugated bile acids. In the present study, protein carbonylation of BAT, consistent with modification by reactive oxygen species and their products, was increased in hepatic homogenates of apo...

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Bibliographic Details
Main Authors: E.M. Shonsey, S.M. Eliuk, M.S. Johnson, S. Barnes, C.N. Falany, V.M. Darley-Usmar, M.B. Renfrow
Format: Article
Language:English
Published: Elsevier 2008-02-01
Series:Journal of Lipid Research
Subjects:
coenzyme A
post-translational modifications
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520428494

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http://www.sciencedirect.com/science/article/pii/S0022227520428494

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