Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.

Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.

Prions are proteinaceous infectious agents responsible for fatal neurodegenerative diseases in animals and humans. They are essentially composed of PrP(Sc), an aggregated, misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrP(C)). Stable variations in PrP(Sc) conformation...

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Bibliographic Details
Main Authors: Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Jérôme Chapuis, Pierre Sibille, Laetitia Herzog, Fabienne Reine, Emilie Jaumain, Hubert Laude, Human Rezaei, Vincent Béringue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130496/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130496/pdf/?tool=EBI

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