Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons

Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons

We report on the effects of ethanol (EtOH) and Poly (ADP-ribose) polymerase (PARP) inhibition on RNA ribosomal engagement, as a proxy for protein translation, in prefrontal cortical (PFC) pyramidal neurons. We hypothesized that EtOH induces a shift in RNA ribosomal-engagement (RE) in PFC pyramidal n...

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Bibliographic Details
Main Authors: Harish R. Krishnan, Gian Paolo Vallerini, Hannah E. Gavin, Marina Guizzetti, Hooriyah S. Rizavi, David P. Gavin, Rajiv P. Sharma
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
TRAP-seq
ribosomal engagement
RNA sequencing
alcohol use disorder (AUD)
PARP (poly(ADP-ribose) polymerase
ABT-888
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1125160/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1125160/full

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