Protective Effect of Edaravone Against Cyclosporine-Induced Chronic Nephropathy Through Antioxidant and Nitric Oxide Modulating Pathways in Rats

Protective Effect of Edaravone Against Cyclosporine-Induced Chronic Nephropathy Through Antioxidant and Nitric Oxide Modulating Pathways in Rats

Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of ed...

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Bibliographic Details
Main Authors: Elahe Sattarinezhad, Mohammad Reza Panjehshahin, Simin Torabinezhad, Eskandar Kamali-Sarvestani, Shirin Farjadian, Fatema Pirsalami, Leila Moezi
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2017-03-01
Series:Iranian Journal of Medical Sciences
Subjects:
Edaravone
Nitric oxide
iNOS
eNOSe
Kidney diseases
Cyclosporine
Online Access:http://ijms.sums.ac.ir/index.php/IJMS/article/view/3002

Internet

http://ijms.sums.ac.ir/index.php/IJMS/article/view/3002

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