Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay.

Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay.

Prion strain identification has been hitherto achieved using time-consuming incubation time determinations in one or more mouse lines and elaborate neuropathological assessment. In the present work, we make a detailed study of the properties of PrP-overproducing Tga20 mice. We show that in these mic...

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Bibliographic Details
Main Authors: Yervand Eduard Karapetyan, Paula Saá, Sukhvir Paul Mahal, Gian Franco Sferrazza, Alexandra Sherman, Nicole Salès, Charles Weissmann, Corinne Ida Lasmézas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2684634?pdf=render

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http://europepmc.org/articles/PMC2684634?pdf=render

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