P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels

P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels

The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage. Nevertheless, the mechanisms by which P2X7 receptor activation induc...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Stephanie Alexia Cristina Silva Santos, Pedro Muanis Persechini, Bianca Monteiro Henriques-Santos, Victória Gabriela Bello-Santos, Newton G. Castro, Júlia Costa de Sousa, Fernando Ariel Genta, Marcelo Felippe Santiago, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio, Eleonora Kurtenbach
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Frontiers Media S.A. 2022-02-01
Loạt:Frontiers in Immunology
Những chủ đề:
lysosomes
P2 receptor
cathepsins
extracellular ATP
lysosomal permeabilization
Truy cập trực tuyến:https://www.frontiersin.org/articles/10.3389/fimmu.2022.752105/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.752105/full

Những quyển sách tương tự