Pentagalloyl Glucose, a Major Compound in Mango Seed Kernel, Exhibits Distinct Gastroprotective Effects in Indomethacin-Induced Gastropathy in Rats via Modulating the NO/eNOS/iNOS Signaling Pathway

Pentagalloyl Glucose, a Major Compound in Mango Seed Kernel, Exhibits Distinct Gastroprotective Effects in Indomethacin-Induced Gastropathy in Rats via Modulating the NO/eNOS/iNOS Signaling Pathway

Gastric ulcers are a common health disorder that affect up to 10% of the world’s population. The gastroprotective potential of pentagalloyl glucose (PGG) against indomethacin-induced ulcer in rats and the possible underlying mechanisms were investigated. Gastric ulceration was induced by indomethaci...

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Bibliographic Details
Main Authors: Mona F. Mahmoud, Mohamed Nabil, Rehab A. Hasan, Assem M. El-Shazly, Mohamed A. El-Ansari, Mansour Sobeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
indomethacin
pentagalloyl glucose
gastric ulcer
iNOS
eNOS
PECAM-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.800986/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.800986/full

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