Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing.

Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing.

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Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ependymal cell ciliary beating to increase hypothalamic glucose sensing. A high lev...

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Bibliographic Details
Main Authors: Francisco Nualart, Manuel Cifuentes, Eder Ramírez, Fernando Martínez, María José Barahona, Luciano Ferrada, Natalia Saldivia, Ernesto R Bongarzone, Bernard Thorens, Katterine Salazar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-09-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002308

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https://doi.org/10.1371/journal.pbio.3002308

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