N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98)

Abstract The type II glycoprotein CD98 (SLC3A2) is a membrane protein with pleiotropic roles in cells, ranging from modulation of inflammatory processes, host–pathogen interactions to association with membrane transporters of the SLC7 family. The recent resolution of CD98 structure in complex with L...

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Bibliographic Details
Main Authors: Lara Console, Mariafrancesca Scalise, Simona Salerno, Raffaella Scanga, Deborah Giudice, Loredana De Bartolo, Annamaria Tonazzi, Cesare Indiveri
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18779-4