E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

Class II HLH proteins heterodimerize with class I HLH/E proteins to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting the neurogenic strength of the distinct proneural proteins. We find that inhibiting BMP signaling or its target ID2 in the chick embryo spinal c...

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Bibliographic Details
Main Authors: Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastian Pons, Marian A Martinez-Balbas, Elisa Marti
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
E proteins
proneural proteins
neurogenesis
neuronal differentiation
ID proteins
bone morphogenetic proteins
Online Access:https://elifesciences.org/articles/37267

Internet

https://elifesciences.org/articles/37267

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