Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

Abstract Background With the large-scale production and application of amorphous silica nanoparticles (aSiNPs), its adverse health effects are more worthy of our attention. Our previous research has demonstrated for the first time that aSiNPs induced cytokinesis failure, which resulted in abnormally...

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Bibliographic Details
Main Authors: Liyan Xiao, Jinyan Pang, Hua Qin, Liyang Dou, Man Yang, Ji Wang, Xianqing Zhou, Yang Li, Junchao Duan, Zhiwei Sun
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Particle and Fibre Toxicology
Subjects:
Amorphous silica nanoparticles
Multinucleation
Cytokinesis
Centralspindlin
Microfilaments
Aurora B
Online Access:https://doi.org/10.1186/s12989-023-00544-8

Internet

https://doi.org/10.1186/s12989-023-00544-8

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