Autophagy-dependent ferroptosis as a potential treatment for glioblastoma
Glioblastoma (GBM) is the most common malignant primary brain tumor with a poor 5-year survival rate. Autophagy is a conserved intracellular degradation system that plays a dual role in GBM pathogenesis and therapy. On one hand, stress can lead to unlimited autophagy to promote GBM cell death. On th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1091118/full |
| _version_ | 1811167209696788480 |
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| author | Yangchun Xie Tao Hou Jinyou Liu Haixia Zhang Xianling Liu Rui Kang Daolin Tang |
| author_facet | Yangchun Xie Tao Hou Jinyou Liu Haixia Zhang Xianling Liu Rui Kang Daolin Tang |
| author_sort | Yangchun Xie |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most common malignant primary brain tumor with a poor 5-year survival rate. Autophagy is a conserved intracellular degradation system that plays a dual role in GBM pathogenesis and therapy. On one hand, stress can lead to unlimited autophagy to promote GBM cell death. On the other hand, elevated autophagy promotes the survival of glioblastoma stem cells against chemotherapy and radiation therapy. Ferroptosis is a type of lipid peroxidation-mediated regulated necrosis that initially differs from autophagy and other types of cell death in terms of cell morphology, biochemical characteristics, and the gene regulators involved. However, recent studies have challenged this view and demonstrated that the occurrence of ferroptosis is dependent on autophagy, and that many regulators of ferroptosis are involved in the control of autophagy machinery. Functionally, autophagy-dependent ferroptosis plays a unique role in tumorigenesis and therapeutic sensitivity. This mini-review will focus on the mechanisms and principles of autophagy-dependent ferroptosis and its emerging implications in GBM. |
| first_indexed | 2024-04-10T16:05:21Z |
| format | Article |
| id | doaj.art-e8da2d9b83a24bb28fc37c41fc7424c7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T16:05:21Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e8da2d9b83a24bb28fc37c41fc7424c72023-02-10T05:36:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.10911181091118Autophagy-dependent ferroptosis as a potential treatment for glioblastomaYangchun Xie0Tao Hou1Jinyou Liu2Haixia Zhang3Xianling Liu4Rui Kang5Daolin Tang6Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United StatesGlioblastoma (GBM) is the most common malignant primary brain tumor with a poor 5-year survival rate. Autophagy is a conserved intracellular degradation system that plays a dual role in GBM pathogenesis and therapy. On one hand, stress can lead to unlimited autophagy to promote GBM cell death. On the other hand, elevated autophagy promotes the survival of glioblastoma stem cells against chemotherapy and radiation therapy. Ferroptosis is a type of lipid peroxidation-mediated regulated necrosis that initially differs from autophagy and other types of cell death in terms of cell morphology, biochemical characteristics, and the gene regulators involved. However, recent studies have challenged this view and demonstrated that the occurrence of ferroptosis is dependent on autophagy, and that many regulators of ferroptosis are involved in the control of autophagy machinery. Functionally, autophagy-dependent ferroptosis plays a unique role in tumorigenesis and therapeutic sensitivity. This mini-review will focus on the mechanisms and principles of autophagy-dependent ferroptosis and its emerging implications in GBM.https://www.frontiersin.org/articles/10.3389/fonc.2023.1091118/fullautophagyferroptosisglioblasomaglioblastom stem cellstherapeutics |
| spellingShingle | Yangchun Xie Tao Hou Jinyou Liu Haixia Zhang Xianling Liu Rui Kang Daolin Tang Autophagy-dependent ferroptosis as a potential treatment for glioblastoma Frontiers in Oncology autophagy ferroptosis glioblasoma glioblastom stem cells therapeutics |
| title | Autophagy-dependent ferroptosis as a potential treatment for glioblastoma |
| title_full | Autophagy-dependent ferroptosis as a potential treatment for glioblastoma |
| title_fullStr | Autophagy-dependent ferroptosis as a potential treatment for glioblastoma |
| title_full_unstemmed | Autophagy-dependent ferroptosis as a potential treatment for glioblastoma |
| title_short | Autophagy-dependent ferroptosis as a potential treatment for glioblastoma |
| title_sort | autophagy dependent ferroptosis as a potential treatment for glioblastoma |
| topic | autophagy ferroptosis glioblasoma glioblastom stem cells therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1091118/full |
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