Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease

Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease

Introduction: Alzheimer’s Disease (AD) patients exhibit signs of motor dysfunction, including gait, locomotion, and balance deficits. Changes in motor function often precede other symptoms of AD as well as correlate with increased severity and mortality. Despite the frequent occurrence of motor dysf...

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Bibliographic Details
Main Authors: Hanna E. Berk-Rauch, Arnab Choudhury, Allison T. Richards, Pradeep K. Singh, Zu-Lin Chen, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
fibrinogen extravasation
vascular degeneration
striatum
motor dysfunction
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1064178/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1064178/full

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