Trio-pharmacophore DNA-encoded chemical library for simultaneous selection of fragments and linkers

Trio-pharmacophore DNA-encoded chemical library for simultaneous selection of fragments and linkers

Dual-pharmacophore DNA-Encoded Libraries (DELs) can generate large libraries, but linker optimisation is challenging. Here, the authors report a trio-pharmacophore DEL (T-DEL) for both de novo fragment identification and linker optimization of known fragment pairs.

Bibliographic Details
Main Authors: Meiying Cui, Dzung Nguyen, Michelle Patino Gaillez, Stephan Heiden, Weilin Lin, Michael Thompson, Francesco V. Reddavide, Qinchang Chen, Yixin Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37071-1

Internet

https://doi.org/10.1038/s41467-023-37071-1

Similar Items