SAR296968, a Novel Selective Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Inhibitor, Improves Ca<sup>2+</sup> Handling and Contractile Function in Human Atrial Cardiomyocytes
Background: In reverse-mode, cardiac sodium-calcium exchanger (NCX) can increase the cytoplasmic Ca<sup>2+</sup> concentration in response to high intracellular Na<sup>+</sup> levels, which may contribute to diastolic contractile dysfunction. Furthermore, increased spontaneou...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-08-01
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Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/10/8/1932 |