SAR296968, a Novel Selective Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Inhibitor, Improves Ca<sup>2+</sup> Handling and Contractile Function in Human Atrial Cardiomyocytes

SAR296968, a Novel Selective Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Inhibitor, Improves Ca<sup>2+</sup> Handling and Contractile Function in Human Atrial Cardiomyocytes

Background: In reverse-mode, cardiac sodium-calcium exchanger (NCX) can increase the cytoplasmic Ca<sup>2+</sup> concentration in response to high intracellular Na<sup>+</sup> levels, which may contribute to diastolic contractile dysfunction. Furthermore, increased spontaneou...

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Bibliographic Details
Main Authors: Philipp Hegner, Marzena Drzymalski, Alexander Biedermann, Bernadette Memmel, Melanie Durczok, Michael Wester, Bernhard Floerchinger, Zdenek Provaznik, Christof Schmid, York Zausig, Lars S. Maier, Stefan Wagner
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
Na<sup>+</sup>/Ca<sup>2+</sup> exchanger
NCX
HFpEF
SAR296968
Online Access:https://www.mdpi.com/2227-9059/10/8/1932

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