CXCL12/SDF-1 facilitates optic nerve regeneration

CXCL12/SDF-1 facilitates optic nerve regeneration

Mature retinal ganglion cells (RGCs) do not normally regenerate injured axons, but undergo apoptosis soon after axotomy. Besides the insufficient intrinsic capability of mature neurons to regrow axons inhibitory molecules located in myelin of the central nervous system as well as the glial scar form...

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Bibliographic Details
Main Authors: Annemarie Heskamp, Marco Leibinger, Anastasia Andreadaki, Philipp Gobrecht, Heike Diekmann, Dietmar Fischer
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neurobiology of Disease
Subjects:
CXCL12/SDF
CXCR4
CNTF
Inflammatory stimulation
Optic nerve regeneration
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001058

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http://www.sciencedirect.com/science/article/pii/S0969996113001058

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