Pulsatilla decoction alleviates DSS-induced UC by activating FXR-ASBT pathways to ameliorate disordered bile acids homeostasis

Pulsatilla decoction alleviates DSS-induced UC by activating FXR-ASBT pathways to ameliorate disordered bile acids homeostasis

Ethnopharmacological relevance: Pulsatilla decoction (PD) is a classical prescription for the treatment of ulcerative colitis. Previous studies have demonstrated that the therapeutic efficacy of PD is closely associated with the activation of Farnesoid X receptor (FXR). The activity of FXR is regula...

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Bibliographic Details
Main Authors: Ying Xiao, Ya-qian Jia, Wen-juan Liu, Chun Niu, Zhan-hai Mai, Jia-qi Dong, Xiao-song Zhang, Zi-wen Yuan, Peng Ji, Yan-ming Wei, Yong-li Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Pharmacology
Subjects:
Pulsatilla decoction
ulcerative colitis
PCR array
bile acid receptor
FXR
ASBT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1399829/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1399829/full

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