Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness

Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness

Breast cancer stem cells (BCSCs) are intrinsically chemoresistant and capable of self-renewal. Following chemotherapy, patients can develop minimal residual disease due to BCSCs which can repopulate into a relapsed tumor. Therefore, it is imperative to co-target BCSCs along with the bulk tumor cells...

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Bibliographic Details
Main Authors: Sangita Sridharan, Megan Robeson, Diwakar Bastihalli-Tukaramrao, Cory M. Howard, Boopathi Subramaniyan, Augustus M. C. Tilley, Amit K. Tiwari, Dayanidhi Raman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
breast cancer stemness
eIF4A
Rocaglamide A
chemoresistance
actionable targets
cell death
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01311/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01311/full

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