COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity

COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity

Cyclooxygenase-2 (COX-2) plays a critical role in regulating innate immunity and metabolism by producing prostaglandins (PGs) and other lipid mediators. However, the implication of adipose COX-2 in obesity remains largely unknown. Using adipocyte-specific COX-2 knockout (KO) mice, we showed that dep...

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Bibliographic Details
Main Authors: Chunqing Wang, Xing Zhang, Liping Luo, Yan Luo, Dandan Wu, Dianna Spilca, Que Le, Xin Yang, Katelyn Alvarez, William Curtis Hines, Xuexian O. Yang, Meilian Liu
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
COX-2
PGE2
white adipogenesis
adipocyte hypertrophy
obesity
PPARγ
Online Access:https://www.mdpi.com/2073-4409/11/11/1819

Internet

https://www.mdpi.com/2073-4409/11/11/1819

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