A novel simian adenovirus-vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

A novel simian adenovirus-vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

ABSTRACT The failure of COVID-19 vaccines to prevent SARS-CoV-2 infection and transmission, a possibly critical reason was the lack of protective mucosal immunity in the respiratory tract. Here, we evaluated the effects of mucosal and systemic immunity from a novel simian adenovirus-vectored COVID-1...

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Bibliographic Details
Main Authors: Panli Zhang, Shengxue Luo, Peng Zou, Qitao Deng, Cong Wang, Jinfeng Li, Peiqiao Cai, Ling Zhang, Chengyao Li, Tingting Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
adenoviral vector
intranasal immunization
mucosal immunity
respiratory virus
vaccination regimen
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01794-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01794-23

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