Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells.

Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells.

The rate of graft survival has dramatically increased using calcineurin inhibitors, however chronic graft rejection and risk of infection are difficult to manage. Induction of allograft-specific regulatory T-cells (Tregs) is considered an ideal way to achieve long-term tolerance for allografts. Howe...

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Bibliographic Details
Main Authors: Fumika Takasato, Rimpei Morita, Takashi Schichita, Takashi Sekiya, Yasuhide Morikawa, Tatsuo Kuroda, Masanori Niimi, Akihiko Yoshimura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912059?pdf=render

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http://europepmc.org/articles/PMC3912059?pdf=render

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