Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis

Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis

Abstract Background Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline into TB drug regimens has improved treatment outcomes, but this advance is threatened by the emergence of strains of Mycobacterium tuberculosis (Mtb) resista...

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Bibliographic Details
Main Authors: Camus Nimmo, Arturo Torres Ortiz, Cedric C. S. Tan, Juanita Pang, Mislav Acman, James Millard, Nesri Padayatchi, Alison D. Grant, Max O’Donnell, Alex Pym, Ola B. Brynildsrud, Vegard Eldholm, Louis Grandjean, Xavier Didelot, François Balloux, Lucy van Dorp
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genome Medicine
Subjects:
Tuberculosis
Phylogenetics
Bedaquiline
Drug resistance
AMR
Online Access:https://doi.org/10.1186/s13073-024-01289-5

Internet

https://doi.org/10.1186/s13073-024-01289-5

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